Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease

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منابع مشابه

Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease.

BACKGROUND Colonic diverticular disease (diverticulosis) is a common disorder in Western countries. Although its pathogenesis is probably multifactorial, motor abnormalities of the large bowel are thought to play an important role. However, little is known about the basic mechanism that may underlie abnormal colon motility in diverticulosis. AIMS To investigate the interstitial cells of Cajal...

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Interstitial cells of Cajal in enteric neurotransmission.

Specialised cells known as interstitial cells of Cajal (ICCs), distributed in specific locations within the tunica muscularis of the gastrointestinal tract, serve as electrical pacemakers and mediators of enteric neurotransmission. Until recently, evidence to support a functional role of these cells has been, for the most part, indirect. The role of ICCs in pacemaking or neurotransmission has b...

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Interplay among enteric neurons, interstitial cells of Cajal, resident and not resident connective tissue cells

is well known that gut motility is regulated by the neurons of the enteric nervous system (ENS), in particular by those located within the ganglia of the myenteric (Auerbach) plexus. John Furness et al. [1] have amply documented that the ENS is composed of a complex network of neurons and in the last decades, utilizing a variety of sophisticated immunohistochemical, electro-physiological, pharm...

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Two Independent Networks of Interstitial Cells of Cajal Work Cooperatively with the Enteric Nervous System to Create Colonic Motor Patterns

Normal motility of the colon is critical for quality of life and efforts to normalize abnormal colon function have had limited success. A better understanding of control systems of colonic motility is therefore essential. We report here a hypothesis with supporting experimental data to explain the origin of rhythmic propulsive colonic motor activity induced by general distention. The theory hol...

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Immunohistochemical studies of the enteric nervous system and interstitial cells of Cajal in the canine stomach.

The distribution of interstitial cells of Cajal (ICC), the probable pacemakers in gastrointestinal motility, was investigated using an antigenic marker of gastric ICC known as C-Kit. Antiserum raised against the general neuronal marker protein gene peptide 9.5 (PGP) as well as the nitrergic neuronal marker neuronal nitric oxide synthase (nNOS) were used to investigate the distribution of gastri...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 2005

ISSN: 0021-9746

DOI: 10.1136/jcp.2005.026112